connectivity map (cmap) (Broad Institute Inc)
90
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Broad Institute Inc
connectivity map (cmap)
Connectivity Map (Cmap), supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/connectivity+map+cmap/connectivity+map++cmap+/pm40517382-1052-38-44
Average 90 stars, based on 1 article reviews
Connectivity Map (Cmap), supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/connectivity+map+cmap/connectivity+map++cmap+/pm40517382-1052-38-44
Average 90 stars, based on 1 article reviews
connectivity map (cmap) - by Bioz Stars,
2026-09
90/100 stars
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Sequencing:Article Title: The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder. Article Snippet: To cite this article: Srisaiyini Kidnapillai, Chiara C Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia M Dean, Tamsyn Crowley, Stéphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk & Ken Walder (2018): The use of a Gene Expression Signature and Connectivity Map to repurpose drugs for Bipolar Disorder, The World Journal of Biological Psychiatry, DOI: 10.1080/15622975.2018.1492734 Article Title: Predictability of drug-induced liver injury by machine learning Article Snippet: Kohonen and colleagues recently proposed a large-scale data-driven modeling approach to build a predictive toxicogenomics space (PTGS) combining the US Broad Institute Connectivity Map (CMap [ ]) and the US National Cancer Institute 60 tumour cell line screen (NCI-60 [ ]). Article Title: Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats Article Snippet: In silico screening involved interrogation of the connectivity map (CMap) from the Broad Institute for drugs that increase FGF20 transcription. Article Title: Agmatine relieves behavioral impairments in Fragile X mice model. Article Snippet: Background: Fragile X syndrome (FXS) is the most common heritable form of neurodevelopmental disorder, which is caused by the loss of fragile X mental retardation protein (FMRP) expression.. Despite the unceasing efforts to develop therapeutic agents against FXS based on the pathophysiological changes observed in animal models of FXS and human patients, therapeutic candidates including mGluR signaling modulators have failed to provide sufficient effects.. Based on the recent successful demonstration of an endogenous polyamine, agmatine, to improve the autism-like symptoms in the valproic acid animal model of autism, we investigated the effects of agmatine against FXS symptoms using Fmr1 knockout (KO) mice. Article Title: Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Age-Related Macular Degeneration Article Snippet: These sources include Broad Institute Connectivity Map (CMap, both up- and downregulation) Comparative Toxicogenomics Database (CTD), and Search Tool for Interactions of Chemicals (STITCH). Article Title: Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Article Snippet: Emulators, i.e., gene modulations and compounds that evoke gene expression changes similar to those evoked by etoposide, were identified using the Connectivity Map (CMap, Broad Institute) [ ]. Biomarker Discovery:Article Title: The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder. Article Snippet: To cite this article: Srisaiyini Kidnapillai, Chiara C Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia M Dean, Tamsyn Crowley, Stéphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk & Ken Walder (2018): The use of a Gene Expression Signature and Connectivity Map to repurpose drugs for Bipolar Disorder, The World Journal of Biological Psychiatry, DOI: 10.1080/15622975.2018.1492734 Article Title: Predictability of drug-induced liver injury by machine learning Article Snippet: Kohonen and colleagues recently proposed a large-scale data-driven modeling approach to build a predictive toxicogenomics space (PTGS) combining the US Broad Institute Connectivity Map (CMap [ ]) and the US National Cancer Institute 60 tumour cell line screen (NCI-60 [ ]). Article Title: Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats Article Snippet: In silico screening involved interrogation of the connectivity map (CMap) from the Broad Institute for drugs that increase FGF20 transcription. Article Title: Agmatine relieves behavioral impairments in Fragile X mice model. Article Snippet: Background: Fragile X syndrome (FXS) is the most common heritable form of neurodevelopmental disorder, which is caused by the loss of fragile X mental retardation protein (FMRP) expression.. Despite the unceasing efforts to develop therapeutic agents against FXS based on the pathophysiological changes observed in animal models of FXS and human patients, therapeutic candidates including mGluR signaling modulators have failed to provide sufficient effects.. Based on the recent successful demonstration of an endogenous polyamine, agmatine, to improve the autism-like symptoms in the valproic acid animal model of autism, we investigated the effects of agmatine against FXS symptoms using Fmr1 knockout (KO) mice. Article Title: Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Age-Related Macular Degeneration Article Snippet: These sources include Broad Institute Connectivity Map (CMap, both up- and downregulation) Comparative Toxicogenomics Database (CTD), and Search Tool for Interactions of Chemicals (STITCH). Article Title: Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Article Snippet: Emulators, i.e., gene modulations and compounds that evoke gene expression changes similar to those evoked by etoposide, were identified using the Connectivity Map (CMap, Broad Institute) [ ]. Gene Expression:Article Title: The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder. Article Snippet: To cite this article: Srisaiyini Kidnapillai, Chiara C Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia M Dean, Tamsyn Crowley, Stéphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk & Ken Walder (2018): The use of a Gene Expression Signature and Connectivity Map to repurpose drugs for Bipolar Disorder, The World Journal of Biological Psychiatry, DOI: 10.1080/15622975.2018.1492734 Article Title: Predictability of drug-induced liver injury by machine learning Article Snippet: Kohonen and colleagues recently proposed a large-scale data-driven modeling approach to build a predictive toxicogenomics space (PTGS) combining the US Broad Institute Connectivity Map (CMap [ ]) and the US National Cancer Institute 60 tumour cell line screen (NCI-60 [ ]). Article Title: Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats Article Snippet: In silico screening involved interrogation of the connectivity map (CMap) from the Broad Institute for drugs that increase FGF20 transcription. Article Title: Agmatine relieves behavioral impairments in Fragile X mice model. Article Snippet: Background: Fragile X syndrome (FXS) is the most common heritable form of neurodevelopmental disorder, which is caused by the loss of fragile X mental retardation protein (FMRP) expression.. Despite the unceasing efforts to develop therapeutic agents against FXS based on the pathophysiological changes observed in animal models of FXS and human patients, therapeutic candidates including mGluR signaling modulators have failed to provide sufficient effects.. Based on the recent successful demonstration of an endogenous polyamine, agmatine, to improve the autism-like symptoms in the valproic acid animal model of autism, we investigated the effects of agmatine against FXS symptoms using Fmr1 knockout (KO) mice. Article Title: Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Age-Related Macular Degeneration Article Snippet: These sources include Broad Institute Connectivity Map (CMap, both up- and downregulation) Comparative Toxicogenomics Database (CTD), and Search Tool for Interactions of Chemicals (STITCH). Article Title: Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells Article Snippet: Emulators, i.e., gene modulations and compounds that evoke gene expression changes similar to those evoked by etoposide, were identified using the Connectivity Map (CMap, Broad Institute) [ ]. |